GRAPHICAL REPRESENTATION OF THE CLINICAL OUTCOME OF ACUTE CORONARY SYNDROME INTO EFFORT ANGINA OF III FUNCTIONAL CLASS AT THE HOSPITAL LEVEL (PART II)
https://doi.org/10.18470/1992-1098-2017-3-75-86
Abstract
Aim. The aim of the research is to study the prognostic value of indices of nonspecific subclinical inflammation, endothelial dysfunction, cardiospecific changes in the immunity system and markers of hypoxic myocardial damage in the clinical outcome of acute coronary syndrome (ACS) into effort angina of the III functional class (FC). Materials and methods. The present work includes the results of examination of 85 patients who entered the infarction department of the Republican Clinical Hospital of the Center for Specialized Emergency Medical Care in Makhachkala. The methods used in the work were conducted according to generally accepted standards. Findings. It is shown that in case of the clinical outcome of ACS into effort angina of the III functional class, the most informative intervals of serum concentrations (points of separation) are: from 30 to 80 pg/ml for the BNP-32 cardiomarker; from 0 to 0.5 pg/ml and TNF-α from 0 to 0.5 pg/ml for IL-1β markers of inflammation; from 20 to 30 μmol/l for markers of endothelial dysfunction NO, from 17 to 18 μmol/l for HC, from 90 to 150 ng/ml for TIMP-1; from 24 to 43 nmol/l for immunomarkers of NP and in 60% of cases there are antibodies to myocardial cells. Conclusion. Based on the obtained findings, were calculated the values of the relative risk of the outcome of ACS into the effort angina of the III FC and was generated a chart flow of the personified short-term prognosis of the clinical outcome of ACS into the effort angina of the III FC at the hospital level. Patients having the indicators which fall within the concentration ranges presented in the prognostic flow chart when entering the hospital (reference point) are a high-risk group for the clinical outcome of ACS into the effort angina of the III FC (end point).
About the Author
Marzhanat G. Alieva
Dagestan State Medical University
Russian Federation
Candidate of Medical Sciences, Associate Professor, Dagestan State Medical University, lead of the infarction department of the Republican Clinical Hospital of the Center for Specialized Emergency Medical Care. Russia, 367000, Makhachkala, st. Pirogov, 3. Теl.: 89634139848.
Russian Federation
Candidate of Medical Sciences, Associate Professor, Dagestan State Medical University, lead of the infarction department of the Republican Clinical Hospital of the Center for Specialized Emergency Medical Care. Russia, 367000, Makhachkala, st. Pirogov, 3. Теl.: 89634139848.
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For citations:
Alieva M.G. GRAPHICAL REPRESENTATION OF THE CLINICAL OUTCOME OF ACUTE CORONARY SYNDROME INTO EFFORT ANGINA OF III FUNCTIONAL CLASS AT THE HOSPITAL LEVEL (PART II). South of Russia: ecology, development. 2017;12(3):75-86. (In Russ.) https://doi.org/10.18470/1992-1098-2017-3-75-86
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