ECOLOGICALLY SAFE BENZIMIDAZOLE-BASED ANTHELMINTIC DRUGS: SYNTHESIS, PROPERTIES, MEDICATION
https://doi.org/10.18470/1992-1098-2016-1-178-192
Abstract
The aim is to study the process of mechanochemical modification of the physico-chemical and anthelmintic benzimidazole properties of drugs to change their water solubility and increase their efficiency.
Methods. We have used the technology of solid phase mechanical processing of substances with polysaccharides to obtain the supramolecular complexes, which are characterized by a complex of physico-chemical methods (IR spectroscopy, DTA, XRF, solubility, etc.) as well as tested for anthelmintic effect in laboratory models and experiments on sheep.
Results. The drug has a high efficiency in laboratory models of helminthes and in experiments on sheep infested spontaneously with nematodes of gastrointestinal tract lowering the dosages of substance.
Conclusion. Solid phase mechanochemical processing of certain substances of benzimidazole anthelmintic drugs with polysaccharides shows the possibility of obtaining environmentally friendly products with improved solubility, bioavailability and increased biological activity against nematodes.
About the Authors
S. S. Khalikov
A.N. Nesmeyanov Institute of Organoelement
Compounds of Russian Academy of Sciences
Russian Federation
Russian Federation
Doctor of Engineering Science, Leading Researcher of the Laboratory of physiologically active organofluorine compounds,
28 Vavilova st., Moscow, 199911
I. A. Arkhipov
Federal State Scientific Institution "K.I. Skryabin All-Russian Research Institute of Fundamental and Applied Parasitology of Animal and Plant"
Russian Federation
Russian Federation
Laboratory of Pharmacology, Toxicology and treatment, Doctor of Veterinary Sciences, Deputy Director,
Moscow
A. I. Varlamova
Federal State Scientific Institution "K.I. Skryabin All-Russian Research Institute of Fundamental and Applied Parasitology of Animal and Plant"
Russian Federation
Russian Federation
Laboratory of Pharmacology, Toxicology and treatment, Candidate of Veterinary Sciences, Senior Researcher,
Moscow
Marat S. Khalikov
All-Russian Research Institute of Phytopathology
Russian Federation
Russian Federation
Junior Researcher at the Department of herbology,
Big Vyazemy, Moscow Region
Yu. S. Chistyachenko
Federal State Institution of Science Institute of Solid State Chemistry and Mechanochemistry, SB RAS
Russian Federation
Russian Federation
Research Group on mechano-chemistry of drugs, postgraduate student,
Novosibirsk
A. V. Dushkin
Federal State Institution of Science Institute of Solid State Chemistry and Mechanochemistry, SB RAS,
Russian Federation
Russian Federation
Research Group on mechano-chemistry of drugs, Doctor of Chemistry, head of the research group,
Novosibirsk
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Review
For citations:
Khalikov S.S., Arkhipov I.A., Varlamova A.I., Khalikov M.S., Chistyachenko Yu.S., Dushkin A.V. ECOLOGICALLY SAFE BENZIMIDAZOLE-BASED ANTHELMINTIC DRUGS: SYNTHESIS, PROPERTIES, MEDICATION. South of Russia: ecology, development. 2016;11(1):178-192. (In Russ.) https://doi.org/10.18470/1992-1098-2016-1-178-192
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