VARIABILITY OF THE INFLUENZA A VIRUS
https://doi.org/10.18470/1992-1098-2016-1-170-177
Abstract
Aim. To investigate the mechanisms of variability of the influenza virus.
Discussion. Influenza is one of the most significant problems facing the health care system. Human influenza causes a number of social and economic problems: mortality in high-risk groups, increasing in the load on personnel agencies health and reduced manpower. Features of the influenza virus genome enable the pathogen to cause seasonal epidemics each year, despite the preventive measures (vaccination) and using of specific antiviral drugs.
Conclusion. Variability of the influenza virus genome is provided by antigenic drift, antigenic shift and recombination. This mechanisms of the variability of influenza virus that allow to remain a highly contagious infectious agent able to infect a large number of host species and cause significant problems as a result of epidemics and pandemics.
About the Authors
I. A. Sobolev
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
Junior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Timakova str, 2, Novosibirsk, 630117
O. G. Kurskaya
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
PhD, Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Novosibirsk
K. A. Sharshov
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
PhD, Senior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Novosibirsk
E. A. Prokopyeva
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
Junior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Novosibirsk
A. Yu. Alekseev
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
PhD, Senior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Novosibirsk
A. A. Gadzhiev
Dagestan State University
Russian Federation
Russian Federation
PhD, Assistant professor, Institute of Ecology and Sustainable Development,
Makhachkala
A. M. Shestopalov
Research Institute of Experimental and Clinical Medicine
Russian Federation
Russian Federation
Doctor of Biological Sciences, Professor, Head of the Laboratory of experimental modeling and pathogenesis of infectious diseases,
Novosibirsk
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Review
For citations:
Sobolev I.A., Kurskaya O.G., Sharshov K.A., Prokopyeva E.A., Alekseev A.Yu., Gadzhiev A.A., Shestopalov A.M. VARIABILITY OF THE INFLUENZA A VIRUS. South of Russia: ecology, development. 2016;11(1):170-177. (In Russ.) https://doi.org/10.18470/1992-1098-2016-1-170-177
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