STRUCTURAL AND METABOLIC CHARACTERISTICS OF COMPENSATORY-ADAPTIVE PROCESSES IN THE HEPATOBILIARY SYSTEM WITH ACETATE GASTRIC AND EXPOSURE TO PESTICIDES
https://doi.org/10.18470/1992-1098-2014-4-132-140
Abstract
Abstract. Aim. To study the structural and metabolic features of the hepatobiliary system for chronic oral exposure to pesticides in combination with acetate gastric ulcer.
Methods. After playing acetate stomach ulcers spent histomorphologically and histoenzymatic research cryostatic and paraffin tissue sections of the liver of experimental and control animals. Set response to succinate dehydroge nase, lactate dehydrogenase, which is glitserofosfatdegidrogenazy, nicotineinduced diaphorase, monoamine oxi dase, acid and alkaline phosphatase; determined the content of glycogen and RNA in the liver with subsequent com puter flow cytometric evaluation.
Results. When injecting pesticides at 1 exposure limit values (ELV) to animals there increase metabolic and protec tiveadaptive processes both in ulcer border zone and in remote fraction of the liver. Increasing doses of pesticides up to 50 ELV and above cause aggressive course of ulcer with penetration into the liver and development of second ary hepatitis, hepatosclerosis and dysfunction of the hepatobiliary system.
Main conclusions. When combined pathology with gastric ulcers modeling (OkabePfeiffer) and chronic oral expo sure of hexachlorocyclohexane, CuSO4, chlorophos pathomorphological changes in the liver are caused by both dose of pesticides and ulcers morphogenesis. The most toxic for the liver from the studied pesticides is hexachloro cyclohexane.
About the Authors
M. A. Shakhnazarov
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia,
Russian Federation
Russian Federation
d.m.n., Professor, head of Department of pathological anatomy of the DSEA, 367000, , Makhachkala street Engels b square 31 geoinformation systems and technologies. 8 8722678995 house. 8 8722 631834.
A. M. Shakhnazarov
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia,
Russian Federation
Russian Federation
k. m. n., assistant Professor of pathological anatomy, the DSEA, 367000, , Makhachkala, Ul. Laptyeva ,42 a, square 6 geoinformation systems and technologies. 8 8 722 67 89 95, mob. 8 988 2917071
M. T. Rasulov
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia,
Russian Federation
Russian Federation
k. m. n., assistant Professor of pathological anatomy, 367029, Republic of Dagestan, Makhachkala, street of Engels 29, square 13. geoinformation systems and technologies. 8 8722 678995 house. 88 722 643303.
M. O. Muslimov
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia,
Russian Federation
Russian Federation
assistant of the Department of skin and venereal diseases of the DSEA, 367000, Republic of Dagestan, Makhachkala street Oleg Koshevoy 31 37 square phone 8 9898797575
Z. A. Buntysheva
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia,
Russian Federation
Russian Federation
Federal STATE budgetary educational institution of higher professional education Dagestan State Medical Academy, Department of Pathological Anatomy, st. Lenina 1, Makhachkala ,Russia
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For citations:
Shakhnazarov M.A., Shakhnazarov A.M., Rasulov M.T., Muslimov M.O., Buntysheva Z.A. STRUCTURAL AND METABOLIC CHARACTERISTICS OF COMPENSATORY-ADAPTIVE PROCESSES IN THE HEPATOBILIARY SYSTEM WITH ACETATE GASTRIC AND EXPOSURE TO PESTICIDES. South of Russia: ecology, development. 2014;9(4):132-140. (In Russ.) https://doi.org/10.18470/1992-1098-2014-4-132-140
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