Ecological, epidemiological and clinical features of toxoplasma invasion in women of reproductive age with immunodeficiency conditions

The aim was to study the ecological, epidemiological and clinical features of toxoplasma invasion in women of reproductive age with obstetric pathology.

112 women of reproductive age (average age 34.5+2.7 years) who were undergoing inpatient treatment at the gynecology department of maternity hospital No 2 of the Ministry of Health of the Republic of Dagestan were examined for toxoplasmosis. Toxoplasmosis was diagnosed based on the results of laboratory, clinical, and epidemiological studies.

The examined women had a complicated obstetric history (miscarriages, stillbirths, fetal malformations). In addition to obstetric pathology, these women also had gynecological pathology (cystitis, endometritis, salpingoophoritis, cervical erosion). The clinical symptoms were polymorphic – lymphadenopathy (8 people), sub-febrile fever (7 people), myalgia and arthralgia (9 people), uveitis (3 people). Women with toxoplasma invasion underwent complex antibacterial therapy with the inclusion of the polyoxidonium immunomodulator (12 mg vaginal suppositories) and the “Selzink-plus” antioxidant complex in the treatment regimen. The clinical and microbiological effectiveness of complex antibacterial therapy was 78.6 %.

The therapy conducted contributed to the regression of clinical symptoms of the disease, a decrease in laboratory parameters and an improvement in the quality of life of the women.

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