MORPHOLOGICAL AND HISTOCHEMIKAL CHANGES OF LIVER IN ACETATE STOMACH ULCER AND CHRONIK INFLUENCE OF HEXACHLORCYCLOHEXAN PESTICIDE
Abstract
On the background of long peroral administration of HChCH at the dose of 10 maximum permissible concentrations (MPC) in animals with an acetate ulcer its penetrations into liver increases (10-20%) with the simultaneous rise of defensive-adaptive metabolic processes in it. With an increase of the dose of the administrated pesticide up to 50-100 MPC the aggressive course of ulcer with an increase of the frequency of its penetration into liver (up to 100% in the dose of 100 MPC) and op-pression of the activity of all the dehydrogenases, MAO, strengthening of glycogenolysis, the drop of RNA synthesis in hepa-tocytes are noticed. Simultaneously, the raised activity of acid phosphatase, alkaline phosphatase is saved that testifies to activization of hydrolytic and fibroblastic processes of the defensive nature.
About the Authors
M. A. Shakhnazarov
Дагестанская государственная медицинская академия
Russian Federation
Russian Federation
A. M. Shakhnazarov
Дагестанская государственная медицинская академия
Russian Federation
Russian Federation
M. T. Rasulov
Дагестанская государственная медицинская академия
Russian Federation
Russian Federation
B. G. Magomedgadzhiev
Дагестанская государственная медицинская академия
Russian Federation
Russian Federation
A. O. Medzhidov
Дагестанская государственная медицинская академия
Russian Federation
Russian Federation
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Review
For citations:
Shakhnazarov M.A., Shakhnazarov A.M., Rasulov M.T., Magomedgadzhiev B.G., Medzhidov A.O. MORPHOLOGICAL AND HISTOCHEMIKAL CHANGES OF LIVER IN ACETATE STOMACH ULCER AND CHRONIK INFLUENCE OF HEXACHLORCYCLOHEXAN PESTICIDE. South of Russia: ecology, development. 2011;6(3):112-117. (In Russ.)
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