Cytotoxicity and antiviral activity of tellurium derivatives in cells infected with herpes simplex virus and cytomegalovirus in vitro
https://doi.org/10.18470/1992-1098-2021-3-108-118
Abstract
Aim. To carry out a comparative analysis of the cytotoxic and antiviral properties of synthesized tellurium derivatives in model cellular systems of infections caused by herpes simplex virus and cytomegalovirus.
Material and Methods. 4 organo‐tellurium compounds were studied using primary and continuous cell cultures in various infection schemes.
Results. For each biological model studied, different thresholds of cytotoxicity concentration (TCD50 acute CC50 and CD50 CC50) were identified. Tellurium derivatives with methoxyphenyl and ethoxyphenyl ethene exhibit virus‐neutralizing activity, preventing the penetration of herpes simplex virus virions into sensitive cells. HTI (SI selectivity index) for these compounds was 84 and 77, respectively.
Conclusion. The manifestation of the cytotoxic effect of all tellurium‐containing organic compounds for transplanted cells lies in a lower concentration than for primary cells. The data obtained in the analysis of antiviral activity showed that the derivatives have therapeutic properties against HSV infection in cell culture.
About the Authors
A. A. AdievaRussian Federation
Aina A. Adieva, Dr of Biological Sciences, Professor & Leading Researcher, Animal Ecology Laboratory
45 Gadzhiev St, Makhachkala, 367000
Теl. +79883005534
R. R. Klimova
Russian Federation
Regina R. Klimova
Moscow
G. M. Abakarov
Russian Federation
Gasan M. Abakarov
Makhachkala
K. S. Bekshokov
Russian Federation
Kerim S. Bekshokov
Makhachkala
N. E. Fedorova
Russian Federation
Natal'ya E. Fedorova
Moscow
D. K. Omarova
Russian Federation
Dzhamilya K. Omarova
Makhachkala
A. A. Kushch
Russian Federation
Alla A. Kushch
Moscow
S. A. Dzhamalova
Russian Federation
Svetlana A. Dzhamalova
Makhachkala
A. M. Khalimbekova
Russian Federation
Aida M. Khalimbekova
Makhachkala
A. R. Guseynova
Russian Federation
Alina R. Guseynova
Omsk
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Review
For citations:
Adieva A.A., Klimova R.R., Abakarov G.M., Bekshokov K.S., Fedorova N.E., Omarova D.K., Kushch A.A., Dzhamalova S.A., Khalimbekova A.M., Guseynova A.R. Cytotoxicity and antiviral activity of tellurium derivatives in cells infected with herpes simplex virus and cytomegalovirus in vitro. South of Russia: ecology, development. 2021;16(3):108‐118. (In Russ.) https://doi.org/10.18470/1992-1098-2021-3-108-118