ecodagЮг России: экология, развитиеSouth of Russia: ecology, development1992-10982413-0958State Institute of Applied Ecology of the Republic of Dagestan10.18470/1992-1098-2016-1-170-177ecodag-814Research ArticleМЕДИЦИНСКАЯ ЭКОЛОГИЯMEDICAL ECOLOGYИЗМЕНЧИВОСТЬ ВИРУСА ГРИППА ТИПА АVARIABILITY OF THE INFLUENZA A VIRUSСоболевИ. А.SobolevI. A.

младший научный сотрудник, лаборатория экспериментального моделирования и патогенеза инфекционных заболеваний,

ул. Тимакова, 2, Новосибирск, 630117

Junior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Timakova str, 2, Novosibirsk, 630117

sobolev_i@hotmail.comКурскаяО. Г.KurskayaO. G.

кандидат биологических наук, научный сотрудник, лаборатория экспериментального моделирования и патогенеза инфекционных заболеваний,

Новосибирск

PhD, Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Novosibirsk

ШаршовК. А.SharshovK. A.

кандидат биологических наук, старший научный сотрудник, лаборатория экспериментального моделирования и патогенеза инфекционных заболеваний,

Новосибирск

PhD, Senior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Novosibirsk

ПрокопьеваЕ. А.ProkopyevaE. A.

младший научный сотрудник, лаборатория экспериментального моделирования и патогенеза инфекционных заболеваний,

Новосибирск

Junior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Novosibirsk

АлексеевА. Ю.AlekseevA. Yu.

кандидат биологических наук, старший научный сотрудник, лаборатория экспериментального моделирования и патогенеза инфекционных заболеваний,

Новосибирск

PhD, Senior Researcher of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Novosibirsk

ГаджиевА. А.GadzhievA. A.

кандидат биологических наук, доцент кафедры экологии,

Махачкала

PhD, Assistant professor, Institute of Ecology and Sustainable Development,

Makhachkala

ШестопаловА. М.ShestopalovA. M.

доктор биологических наук, профессор, заведующий лабораторией экспериментального моделирования и патогенеза инфекционных заболеваний,

Новосибирск

Doctor of Biological Sciences, Professor, Head of the Laboratory of experimental modeling and pathogenesis of infectious diseases,

Novosibirsk

Научно-исследовательский институт экспериментальной и клинической медициныРоссияResearch Institute of Experimental and Clinical MedicineRussian FederationИнститут экологии и устойчивого развития Дагестанского государственного университетаРоссияDagestan State UniversityRussian Federation201630032016111170177Copyright © Соболев И.А., Курская О.Г., Шаршов К.А., Прокопьева Е.А., Алексеев А.Ю., Гаджиев А.А., Шестопалов А.М., 20162016Соболев И.А., Курская О.Г., Шаршов К.А., Прокопьева Е.А., Алексеев А.Ю., Гаджиев А.А., Шестопалов А.М.Sobolev I.A., Kurskaya O.G., Sharshov K.A., Prokopyeva E.A., Alekseev A.Y., Gadzhiev A.A., Shestopalov A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://ecodag.elpub.ru/ugro/article/view/814Цель

Цель. Рассмотреть механизмы изменчивости вируса гриппа.

Обсуждение

Обсуждение. Грипп представляет собой одну из наиболее значимых проблем, стоящих перед современной системой здравоохранения. Характер заболеваемости гриппом обусловливает ряд проблем социального и экономического характера: смертность в группах риска, резкое повышение нагрузки на персонал учреждений системы здравоохранения и снижение трудовых ресурсов. Особенности генома вируса гриппа позволяют этому патогену ежегодно вызывать сезонные эпидемии, несмотря на профилактические мероприятия (вакцинация) и наличие специфических лекарственных препаратов.

Заключение

Заключение. Изменчивость генома вируса гриппа обеспечивается антигенным дрейфом, антигенным шифтом и рекомбинацией. Эти механизмы позволяют вирусу на протяжении долгого времени оставаться высоко-контагиозным инфекционным агентом, способным поражать большое количество видов-хозяев и наносить значительный вред в результате эпидемий и пандемий.

Aim

Aim. To investigate the mechanisms of variability of the influenza virus.

Discussion

Discussion. Influenza is one of the most significant problems facing the health care system. Human influenza causes a number of social and economic problems: mortality in high-risk groups, increasing in the load on personnel agencies health and reduced manpower. Features of the influenza virus genome enable the pathogen to cause seasonal epidemics each year, despite the preventive measures (vaccination) and using of specific antiviral drugs.

Conclusion

Conclusion. Variability of the influenza virus genome is provided by antigenic drift, antigenic shift and recombination. This mechanisms of the variability of influenza virus that allow to remain a highly contagious infectious agent able to infect a large number of host species and cause significant problems as a result of epidemics and pandemics.

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The authors declare that there are no conflicts of interest present.