ecodagЮг России: экология, развитиеSouth of Russia: ecology, development1992-10982413-0958State Institute of Applied Ecology of the Republic of Dagestan10.18470/1992-1098-2021-4-86-103ecodag-2346Research ArticleЭКОЛОГИЯ МИКРООРГАНИЗМОВОсобенности антагонизма бактерий рода Bacillus по отношению к токсиногенным грибам Fusarium при защите растений от болезни и контаминации микотоксинами (обзор)Specific features of antagonism of Bacillus bacteria against toxinogenic Fusarium fungi in protecting plants against disease and contamination with mycotoxins (review)https://orcid.org/0000-0003-4281-5278СидороваТ. М.SidorovaT. M.

Татьяна М. Сидорова, кандидат биологических наук, старший научный сотрудник350039, Краснодарский край, г. Краснодар, п/о 39Тел. +79280387012

Tatyana M. Sidorova, PhD in Biology, Senior Researcherp/o 39 Krasnodar, Krasnodar Krai, 350039Tel. +79280387012

0166505@mail.ruhttps://orcid.org/0000-0002-0060-1995АсатуроваА. М.AsaturovaA. M.

Анжела М. АсатуроваКраснодар

Anzhela M. AsaturovaKrasnodar

https://orcid.org/0000-0002-8679-6139АллахвердянВ. В.AllakhverdyanV. V.

Валерия В. АллахвердянКраснодар

Valeria V. AllakhverdyanKrasnodar

Федеральное государственное бюджетное научное учреждение «Федеральный научный центр биологической защиты растений»Federal Research Center of Biological Plant Protection20210901202216486‐103Copyright © Сидорова Т.М., Асатурова А.М., Аллахвердян В.В., 20222022Сидорова Т.М., Асатурова А.М., Аллахвердян В.В.Sidorova T.M., Asaturova A.M., Allakhverdyan V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ecodag.elpub.ru/ugro/article/view/2346

Цель. Обобщить и проанализировать сведения о результатах исследований по изучению антагонистических свойств бактерий рода Bacillus в отношении фитопатогенных грибов рода Fusarium.Материалы и методы. Изучены и критически проанализированы современные сведения исследований российских и зарубежных ученых о роли бактерий рода Bacillus для подавления фузариозных болезней растений и загрязнения растительной продукции микотоксинами.Результаты. Обобщены сведения о перспективах применения бактерий‐антагонистов фитопатогенных грибов рода Bacillus для защиты растений от болезней, вызванных токсиногенными грибами рода Fusarium. Показана роль продуцируемых бактериями липопептидов в ингибировании роста грибов, которая проявляется как за счет разрушения клеточной стенки гриба, так и путем повышения иммунного статуса растения. Содержится информация о структуре и механизме действия основных антигрибных циклических липопептидов. Раскрыты особенности проявления антагонистических свойств бактерий Bacillus, которые заключаются в способности метаболитов бактерий осуществлять деструкцию микотоксинов, что может способствовать снижению их токсичности. Обосновывается перспективность поиска штаммов бактерий рода Bacillus, пригодных для создания эффективных биофунгицидов против фузариозных грибов.Заключение. Знание механизмов действия бактерий рода Bacillus – антагонистов грибов Fusarium будет способствовать тщательному подбору перспективных для разработки эффективных биопрепаратов штаммов для замены химических фунгицидов на биофунгициды в контроле F. graminearum и его микотоксинов, что позволит получить продукцию, необремененную ни химическими средствами защиты, ни опасными для потребителей микотоксинами.

Aim. Summarize and analyze information on the results of studies on the antagonistic properties of Bacillus bacteria against phytopathogenic fungi of the genus Fusarium.Materials and Methods. Current information of research by Russian and foreign scientists on the role of bacteria of the genus Bacillus to suppress Fusarium diseases of plants and contamination of plant products with mycotoxins was studied and critically analysed.Results. Information on the prospects for the use of bacteria‐antagonists of phytopathogenic fungi of the genus Bacillus for plant protection against diseases caused by toxinogenic fungi of the genus Fusarium has been generalized. The role of lipopeptides produced by bacteria in inhibiting the growth of fungi, which manifests itself both through the destruction of the cell wall of the fungus and by increasing the immune status of the plant, has been shown. The study contains information on the structure and mechanism of action of the main anti‐fungal cyclic lipopetides. The features of the manifestation of the antagonistic properties of Bacillus bacteria, which consist in the ability of bacterial metabolites to destroy mycotoxins which can help to reduce their toxicity, have been disclosed. The prospect of searching for bacterial strains of the genus Bacillus suitable for creating effective biofungicides against Fusarium fungi is substantiated.Conclusion. Knowledge of the mechanisms of action of bacteria of the genus Bacillus as antagonists of Fusarium fungi will contribute to the careful selection of strains that are promising for the development of effective biological products for replacing chemical fungicides with biofungicides in the control of F. graminearum and its mycotoxins, which will make it possible to obtain products that are not burdened with either chemical means of protection or mycotoxins which are dangerous for consumers.

Антагонизмгрибы рода Fusariumбактерии рода BacillusлипопептидымикотоксиныдезоксиниваленолAntagonismFusarium fungiBacillus bacterialipopeptidesmycotoxinsdeoxynivalenolИсследования выполнены согласно Государственного задания Министерства науки и высшего образования РФ в рамках НИР по теме No 0495‐2019‐0001 «Разработка технической документации на производство и применение биологических средств защиты растений, применяемых в технологиях биологизированного и органического земледелия».The studies were carried out in accordance with the State Assignment of the Ministry of Science and Higher Education of the Russian Federation within the framework of research work on the topic No. 0495‐2019‐0001 “Development of technical documentation for the production and use of biological agents protection of plants used in technologies of biologized and organic farming”.ReferencesЛевитин М.М., Джавахия В.Г. Токсигенные грибы и проблемы продовольственной безопасности (обзор) // Достижения науки и техники АПК. 2020. Т. 34. N12. С. 5‐ 11. DOI: 10.24411/0235‐2451‐2020‐11201Levitin M.M., Dzhavahija V.G. Toxigenic fungi and food security problems (review). Achievements of science and technology of the agro‐industrial complex, 2020, vol. 34, no. 12, pp. 5‐11. (In Russian) DOI: 10.24411/0235‐2451-2020‐11201Гагкаева Т.Ю., Гаврилова О.П., Левитин М.М., Новожилов К.В. Фузариоз зерновых культур // Защита и карантин растений. 2011. N5. С. 69‐120.Gagkaeva T.Ju., Gavrilova O.P., Levitin M.M., Novozhilov K.V. Fusarium of cereals. Zashchita i karantin rastenii [Plant protection and quarantine]. 2011, no. 5, pp. 69‐120. (In Russian)Гагкаева Т.Ю., Гаврилова О.П., Орина А.С. Выявление токсинопродуцирующих грибов рода Fusarium в зерне озимой пшеницы в Центральном регионе Европейской части России // Успехи медицинской микологии. 2018. Т. 19. N9. С. 299‐303.Gagkaeva T.Yu., Gavrilova O.P., Orina A.S. Identification of toxin‐producing fungi of the genus Fusarium in winter wheat grain in the Central region of the European part of Russia. Uspekhi meditsinskoi mikologii [Advances in medical mycology]. 2018, vol. 19, no. 9, pp. 299‐303. (In Russian)Соколова Г.Д., Глинушкин А.П. Антагонисты фитопатогенного гриба Fusarium graminearum // Микология и фитопатология. 2017. Т. 51. N4. С. 191‐201.Sokolova G.D., Glinushkin A.P. Antagonists of the phytopathogenic fungus Fusarium graminearum. Mikologiya i fitopatologiya [Mycology and phytopathology]. 2017, vol. 51, no. 4, pp. 191‐201. (In Russian)Bertero A., Moretti A., Spicer L.J., Caloni F. Fusarium molds and mycotoxins: potential species‐specific effects // Toxins (Basel). 2018. V. 10. N6. 244 p. DOI: 10.3390/toxins10060244Bertero A., Moretti A., Spicer L.J., Caloni F. Fusarium molds and mycotoxins: potential species‐specific effects // Toxins (Basel). 2018. V. 10. N6. 244 p. DOI: 10.3390/toxins10060244Tan J., Ameye M., Landschoot S., De Zutter N., De Saeger S., De Boevre M., Abdallah M.F., Van der Lee T., Wallwijk C., Audenaert K. At the scene of the crime: new insights into the role of weakly pathogenic members of the Fusarium head blight disease complex // Mol. plant. pathol. 2020. V. 21. N12. P. 1559‐1572. DOI: 10.1111/mpp.12996Tan J., Ameye M., Landschoot S., De Zutter N., De Saeger S., De Boevre M., Abdallah M.F., Van der Lee T., Wallwijk C., Audenaert K. At the scene of the crime: new insights into the role of weakly pathogenic members of the Fusarium head blight disease complex // Mol. plant. pathol. 2020. V. 21. N12. P. 1559‐1572. DOI: 10.1111/mpp.12996Pickova D., Ostry V., Malir J., Toman J., Malir F. A review on mycotoxins and microfungi in spices in the light of the last five years // Toxins (Basel). 2020. V. 12. N12. 789 p. DOI: 10.3390/toxins12120789Pickova D., Ostry V., Malir J., Toman J., Malir F. A review on mycotoxins and microfungi in spices in the light of the last five years // Toxins (Basel). 2020. V. 12. N12. 789 p. DOI: 10.3390/toxins12120789Pellan L., Durand N., Martinez V., Fontana A., Schorr-Galino S., Strub C. Commercial biocontrol agents reveal contrasting comportments against two mycotoxigenic fungi in cereals: Fusarium graminearum and Fusarium verticillioides // Toxins. 2020. V. 12. 152 p. DOI: 10.3390/toxins12030152Pellan L., Durand N., Martinez V., Fontana A., Schorr-Galino S., Strub C. Commercial biocontrol agents reveal contrasting comportments against two mycotoxigenic fungi in cereals: Fusarium graminearum and Fusarium verticillioides // Toxins. 2020. V. 12. 152 p. DOI: 10.3390/toxins12030152Penha R.O., Vandenberghe L.P.S., Faulds C., Soccol V.T., Soccol C.R. Bacillus lipopeptides as powerful pest control agents for a more sustainable and healthy agriculture: recent studies and innovations // Planta. 2020. V. 25. N1. 70 p. DOI: 10.1007/s00425‐020‐03357‐7Penha R.O., Vandenberghe L.P.S., Faulds C., Soccol V.T., Soccol C.R. Bacillus lipopeptides as powerful pest control agents for a more sustainable and healthy agriculture: recent studies and innovations // Planta. 2020. V. 25. N1. 70 p. DOI: 10.1007/s00425‐020‐03357‐7Pan D., Mionetto A., Tiscornia S., Bettucci L. Endophytic bacteria from wheat grain as biocontrol agents of Fusarium graminearum and deoxynivalenol production in wheat // Mycotoxin. 2015. V. 31. P. 137‐143. DOI: 10.1007/s12550‐015‐0224‐8Pan D., Mionetto A., Tiscornia S., Bettucci L. Endophytic bacteria from wheat grain as biocontrol agents of Fusarium graminearum and deoxynivalenol production in wheat // Mycotoxin. 2015. V. 31. P. 137‐143. DOI: 10.1007/s12550‐015‐0224‐8Vahidinasab M., Lilge L., Reinfurt A., Pflannstiel A., Pflannstiel J., Henkel M., Heravi K.M., Hausman R. Construction and description of a constitutive plipastatin mono‐producing Bacillus subtilis // Microb. cell. fact. 2020. V. 19. 205 p. DOI: 10.1186/s12934‐020‐01468‐0Vahidinasab M., Lilge L., Reinfurt A., Pflannstiel A., Pflannstiel J., Henkel M., Heravi K.M., Hausman R. Construction and description of a constitutive plipastatin mono‐producing Bacillus subtilis // Microb. cell. fact. 2020. V. 19. 205 p. DOI: 10.1186/s12934‐020‐01468‐0Miljaković D., Marinković J., Balešević‐Tubić S. The Significance of Bacillus spp. in Disease Suppression and Growth Promotion of Field and Vegetable Crops // Microorganisms. 2020. V. 8. N7. 1037 p. DOI: 10.3390/microorganisms8071037Miljaković D., Marinković J., Balešević‐Tubić S. The Significance of Bacillus spp. in Disease Suppression and Growth Promotion of Field and Vegetable Crops // Microorganisms. 2020. V. 8. N7. 1037 p. DOI: 10.3390/microorganisms8071037Kang X., Zhang W., Cai X., Tong Z., XueY., Liu C. Bacillus velezensis CCO9: a potential «vaccine» for controlling wheat diseases // Published online, 2018. V. 31. N6. DOI: 10.1094/MPMI‐09‐17‐0227‐RKang X., Zhang W., Cai X., Tong Z., XueY., Liu C. Bacillus velezensis CCO9: a potential «vaccine» for controlling wheat diseases // Published online, 2018. V. 31. N6. DOI: 10.1094/MPMI‐09‐17‐0227‐RLegard F., Picot A., Cobo‐Diaz J.F., Chen W., Le Floch G. Challenges facing the biological control strategies for the management of Fusarium head blight of cereals caused by F. graminearum // Biological control. 2017. V. 11. P. 26‐38. DOI: 10.1016/j.biocontrol.2017.06.11Legard F., Picot A., Cobo‐Diaz J.F., Chen W., Le Floch G. Challenges facing the biological control strategies for the management of Fusarium head blight of cereals caused by F. graminearum // Biological control. 2017. V. 11. P. 26‐38. DOI: 10.1016/j.biocontrol.2017.06.11Сидорова Т.М., Асатурова А.М., Хомяк А.И. Биологически активные метаболиты Bacillus subtilis и их роль в контроле фитопатогенных микроорганизмов (обзор) // Сельскохозяйственная биология. 2018. N1. С. 29‐37. DOI: 10.1589/agrobiology.2018.1.29rusSidorova T.M., Asaturova A.M., Homjak A.I. Biologically active metabolites of Bacillus subtilis and their role in the control of phytopathogenic microorganisms (review). Agricultural Biology, 2018, vol. 53, no. 1, pp. 29‐37. (In Russian) DOI: 10.1589/agrobiology.2018.1.29rusМаксимов И.В., Сингх Б.П., Черепанова Е.А., Бурханова Г.Ф., Хайруллин Р.М. Перспективы применения бактерий – продуцентов липопептидов для защиты растений // Прикладная биохимия и микробиология. 2020. N1. С. 19‐54. DOI: 10.31857/s0555109920010134Maksimov I.V., Singh B.P., Cherepanova E.A., Burhanova G.F., Hajrullin R.M. Prospects for the use of bacteria ‐ lipopeptide producers for plant protection. Applied Biochemistry and Microbiology, 2020, vol. 56, no. 1, pp. 19‐54. (In Russian) DOI: 10.31857/s0555109920010134Köhl J., Kolnaar R., Ravensberg W.J. Мode of action of microbial biological control agents against plant diseases: relevance beyond efficacy // Frontiers in plant science. 2019. V. 10. 845 p. DOI: 10.3389/fpls.2019.00845Köhl J., Kolnaar R., Ravensberg W.J. Мode of action of microbial biological control agents against plant diseases: relevance beyond efficacy // Frontiers in plant science. 2019. V. 10. 845 p. DOI: 10.3389/fpls.2019.00845Gong A.D., Li H.P., Yuan Q.S., Song X.S., Yao W., He W.J., Zhang J.B., Liao Y.C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliqiefaciens S76‐3 from wheat spikes against Fusarium graminearum // PLosOne. 2015. V. 10. Iss. 2. e0116871. DOI: 10.1371/journal.pone.0116871Gong A.D., Li H.P., Yuan Q.S., Song X.S., Yao W., He W.J., Zhang J.B., Liao Y.C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliqiefaciens S76‐3 from wheat spikes against Fusarium graminearum // PLosOne. 2015. V. 10. Iss. 2. e0116871. DOI: 10.1371/journal.pone.0116871Cai X.C., Liu C.H., Wang B.T., Xue Y.R. Genomic and metabolic traits endow Bacillus velezensis CC09 with a potential biocontrol agent in control of wheat powdery mildew disease // Microbiol. Res. 2017. V. 196. P. 89‐94. DOI: 10.1016/j.micres.2016.12.007Cai X.C., Liu C.H., Wang B.T., Xue Y.R. Genomic and metabolic traits endow Bacillus velezensis CC09 with a potential biocontrol agent in control of wheat powdery mildew disease // Microbiol. Res. 2017. V. 196. P. 89‐94. DOI: 10.1016/j.micres.2016.12.007Salasar F., Ortiz A., Sansinenea E. Characterisation of two novel bacteriocin‐like substances produced by Bacillus amyloliquefaciens ELI149 with broad‐spectrum antimicrobial activity // Journal of global antimicrobial resistance. 2017. V. 11. P. 177‐182. DOI: 10.1016/j.jgar.2017.08.008Salasar F., Ortiz A., Sansinenea E. Characterisation of two novel bacteriocin‐like substances produced by Bacillus amyloliquefaciens ELI149 with broad‐spectrum antimicrobial activity // Journal of global antimicrobial resistance. 2017. V. 11. P. 177‐182. DOI: 10.1016/j.jgar.2017.08.008Palazzini J.M., Dunlap C.A., Bowman M.J., Chulze S.N. Bacillus velezensis RC 218 as a biocontrol agent to reduce Fusarium head blight and deoxynivalenol accumulation: Genome sequencing and secondary metabolite cluster profiles // Microbiol Res. 2016. V. 19. P. 30‐36. DOI: 10.1016/j.micres.2016.06.002Palazzini J.M., Dunlap C.A., Bowman M.J., Chulze S.N. Bacillus velezensis RC 218 as a biocontrol agent to reduce Fusarium head blight and deoxynivalenol accumulation: Genome sequencing and secondary metabolite cluster profiles // Microbiol Res. 2016. V. 19. P. 30‐36. DOI: 10.1016/j.micres.2016.06.002Патент на изобретение N 2552146 от 29.04.2015 «Штамм бактерий Bacillus subtilis BZR 517 для получения биопрепарата против фитопатогенных грибов».Asaturova A.M., Dubjaga V.M. Bacillus subtilis BZR 517 bacterial strain for obtaining a biological product against phytopathogenic fungi. Patent RF, no. 2552146, 2015.Патент на изобретение N 2553518 от 20.05.2015 «Штамм бактерий Bacillus subtilis BZR 336g для получения биопрепарата против фитопатогенных грибов».Asaturova A.M., Dubjaga V.M. Bacillus subtilis BZR 336g bacterial strain for obtaining a biological product against phytopathogenic fungi. Patent RF, no. 2553518, 2015.Сидорова Т.М., Асатурова А.М., Хомяк А.И., Томашевич Н.С. Выделение и характеристика антигрибных метаболитов штаммов Bacillus subtilis BZR 336g и Bacillus subtilis BZR517 модифицированным методом биоавтографии // Сельскохозяйственная биология. 2019. N1. С. 178‐185. DOI: 10.15389/agrobiology.2019.1.178rusSidorova T.M., Asaturova A.M., Homjak A.I., Tomashevich N.S. Isolation and characterization of antifungal metabolites of Bacillus subtilis BZR 336g and Bacillus subtilis BZR517 strains by a modified bioautography method. Agricultural biology, 2019, vol. 54, no. 1, pp. 178‐185. (In Russian) DOI: 10.15389/agrobiology.2019.1.178rusKim К., Lee Y., Ha A., Kim J.I., Park A.R., Yu N.H., Son H., Choi G.J., Park H.W., Lee C.W., Lee T., Lee Y.W., Kim J.C. Chemosensitization of Fusarium graminearum to chemical fungicides using cyclic lipopeptides produced by Bacillus amyloliquefaciens strain JCK‐12 // Frontiers in plant science. 2017. V. 8. DOI: 10.3389/fpls.2017.02010Kim К., Lee Y., Ha A., Kim J.I., Park A.R., Yu N.H., Son H., Choi G.J., Park H.W., Lee C.W., Lee T., Lee Y.W., Kim J.C. Chemosensitization of Fusarium graminearum to chemical fungicides using cyclic lipopeptides produced by Bacillus amyloliquefaciens strain JCK‐12 // Frontiers in plant science. 2017. V. 8. DOI: 10.3389/fpls.2017.02010Xu W., Zhang L., Goodwin P.H., Xia M., Zhang J., Wang Q., Liang J., Sun R., Wu C., Yang L. Isolation, identification, and complete genome assembly of an endophytic Bacillus velezensis YB‐130, potential biocontrol agent against Fusarium graminearum // Front. Microbial. 2020. V. 11. DOI: 10.3389/fmicb.2020.598285Xu W., Zhang L., Goodwin P.H., Xia M., Zhang J., Wang Q., Liang J., Sun R., Wu C., Yang L. Isolation, identification, and complete genome assembly of an endophytic Bacillus velezensis YB‐130, potential biocontrol agent against Fusarium graminearum // Front. Microbial. 2020. V. 11. DOI: 10.3389/fmicb.2020.598285Fira D., Dimkić I., Berić T., Lozo J., Stanković S. Biological control of plant pathogens by Bacillus species // J Biotechnol. 2018. V. 285. P. 44‐55. DOI: 10.1016/j.jbiotec.2018.07.044Fira D., Dimkić I., Berić T., Lozo J., Stanković S. Biological control of plant pathogens by Bacillus species // J Biotechnol. 2018. V. 285. P. 44‐55. DOI: 10.1016/j.jbiotec.2018.07.044Ntushelo K., Ledwaba L.K., Rauwane M.E., Adebo O.A., Njobeh P.B. The mode of action of Bacillus species against Fusarium graminearum, tools for investigation, and future prospects // Toxins (Basel). 2019. V. 11. N10. 606 p. DOI: 10.3390/toxins11100606Ntushelo K., Ledwaba L.K., Rauwane M.E., Adebo O.A., Njobeh P.B. The mode of action of Bacillus species against Fusarium graminearum, tools for investigation, and future prospects // Toxins (Basel). 2019. V. 11. N10. 606 p. DOI: 10.3390/toxins11100606Hazarika D.J., Goswami G., Gautom T., Parveen A., Das P., Barooah M., Chandra R. Lipopeptide mediated biocontrol activity of endophytic Bacillus subtilis against fungal phytopathogens // BMC Microbiol. 2019. V. 19. 71 p. DOI: 10.1186/s12866‐019‐1440‐8Hazarika D.J., Goswami G., Gautom T., Parveen A., Das P., Barooah M., Chandra R. Lipopeptide mediated biocontrol activity of endophytic Bacillus subtilis against fungal phytopathogens // BMC Microbiol. 2019. V. 19. 71 p. DOI: 10.1186/s12866‐019‐1440‐8Zhang F., Huo K., Song X., Quan Y., Wang S., Zhang Z., Gao W., Yang C. Engineering of a genome‐reduced strain Bacillus amyloliquefaciens for enhancing surfactin production // Microb. Cell.fact. 2020. V. 19. 223 p. DOI: 10.1186/s12934‐020‐01485‐zZhang F., Huo K., Song X., Quan Y., Wang S., Zhang Z., Gao W., Yang C. Engineering of a genome‐reduced strain Bacillus amyloliquefaciens for enhancing surfactin production // Microb. Cell.fact. 2020. V. 19. 223 p. DOI: 10.1186/s12934‐020‐01485‐zRabbee M.F., Ali M. S., Choi J., Hwang B.S., Jeong S.C., Baek K.H. Bacillus velezensis: a valuable member of bioactive molecules within plant microbiomes // Molecules (Basel, Switzerland). 2019. V. 24. N6. 1046 p. DOI: 10.3390/molecules24061046Rabbee M.F., Ali M. S., Choi J., Hwang B.S., Jeong S.C., Baek K.H. Bacillus velezensis: a valuable member of bioactive molecules within plant microbiomes // Molecules (Basel, Switzerland). 2019. V. 24. N6. 1046 p. DOI: 10.3390/molecules24061046Stein T. Bacillus subtilis antibiotics: Structures, synthesis and specific functions // Mol. Microbiol. 2005. V. 56. P. 845‐857. DOI: 10.1111/j.1365‐2958.2005.04587.xStein T. Bacillus subtilis antibiotics: Structures, synthesis and specific functions // Mol. Microbiol. 2005. V. 56. P. 845‐857. DOI: 10.1111/j.1365‐2958.2005.04587.xCaulier S., Nannan C., Gillis A., Licciardi F., Bragard C., Mahillon J. Overview of the antimicrobial compounds produced by members of the Bacillus subtilis group // Front. Microbiol. 2019. V. 10. 302 p. DOI: 10.3389/fmicb.2019.00302Caulier S., Nannan C., Gillis A., Licciardi F., Bragard C., Mahillon J. Overview of the antimicrobial compounds produced by members of the Bacillus subtilis group // Front. Microbiol. 2019. V. 10. 302 p. DOI: 10.3389/fmicb.2019.00302Malviya D., Sahu P.K., Singh U.B., Paul S., Gupta A., Gupta A.K., Singh S., Kumar M., Paul D., Rai J.P., Singh H.V., Brahmaprakash G.P. Lesson from ecotoxity: revising the microbial lipopeptides for the management of emerging diseases of crop protection // Int J. Environ Res Public Health. 2020. V. 17. Iss. 4. 1434 p. DOI: 10.3390/ijerph17041434Malviya D., Sahu P.K., Singh U.B., Paul S., Gupta A., Gupta A.K., Singh S., Kumar M., Paul D., Rai J.P., Singh H.V., Brahmaprakash G.P. Lesson from ecotoxity: revising the microbial lipopeptides for the management of emerging diseases of crop protection // Int J. Environ Res Public Health. 2020. V. 17. Iss. 4. 1434 p. DOI: 10.3390/ijerph17041434Yaseen Y., Diop A., Gancel F., Béchet M., Jacques P., Drider D. Polynucleotide phosphorylase is involved in the control of lipopeptide fengycin production in Bacillus subtilis // Arch Microbiol. 2018. V. 200. P. 783‐791. DOI: 10.1007/s00203‐018‐1483‐5Yaseen Y., Diop A., Gancel F., Béchet M., Jacques P., Drider D. Polynucleotide phosphorylase is involved in the control of lipopeptide fengycin production in Bacillus subtilis // Arch Microbiol. 2018. V. 200. P. 783‐791. DOI: 10.1007/s00203‐018‐1483‐5Zhao X., Kuipers O.P. Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species // BMC Genomics. 2016. V. 17. pp. 882. DOI: 10.1186/s12864‐016‐3224‐yZhao X., Kuipers O.P. Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species // BMC Genomics. 2016. V. 17. pp. 882. DOI: 10.1186/s12864‐016‐3224‐yAleti G., Lehner S., Bacher M., Compant S., Nikolic B., Plesko M., Schumacher R., Sessitsch A., Lehner S., Brader G. Surfactin variants mediate species‐specific biofilm formation and root colonization in Bacillus // Environ. Microbial. 2016. V. 18. N8. P. 2634‐2645. DOI: 10.1111/1462‐2920.13405Aleti G., Lehner S., Bacher M., Compant S., Nikolic B., Plesko M., Schumacher R., Sessitsch A., Lehner S., Brader G. Surfactin variants mediate species‐specific biofilm formation and root colonization in Bacillus // Environ. Microbial. 2016. V. 18. N8. P. 2634‐2645. DOI: 10.1111/1462‐2920.13405Lozo J., Topisirovic L., Kojic M. Natural bacterial isolates as an inexhaustible source of new bacteriocins // Appl. Microbiol. Biotechnol. 2021. V. 105. P. 477‐492. DOI: 10.1007/s00253‐020‐11063‐3Lozo J., Topisirovic L., Kojic M. Natural bacterial isolates as an inexhaustible source of new bacteriocins // Appl. Microbiol. Biotechnol. 2021. V. 105. P. 477‐492. DOI: 10.1007/s00253‐020‐11063‐3Fan H., Ru J., Zhang Y., Wang Q., Li Y. Fengycin produced by Bacillus subtilis 9407 plays a major role in the biocontrol of apple ring rot disease // Microbiol Res. 2017. V. 199. P. 89‐97. DOI: 10.1016/j.micres.2017.03.004Fan H., Ru J., Zhang Y., Wang Q., Li Y. Fengycin produced by Bacillus subtilis 9407 plays a major role in the biocontrol of apple ring rot disease // Microbiol Res. 2017. V. 199. P. 89‐97. DOI: 10.1016/j.micres.2017.03.004Hanif A., Zhang F., Li P., Li C., Xu Y., Zubair M., Zhang M., Jia D., Zhao X., Liang J., Majid T., Yan J., Farzand A., Wu H., Gu Q., Gao X. Fengycin produced by Bacillus amyloliquefaciens FZB42 inhibits Fusarium graminearum growth and mycotoxins biosynthesis // Toxins (Basel). 2019. V. 11. N5. pp. 295. DOI: 10.3390/toxins11050295Hanif A., Zhang F., Li P., Li C., Xu Y., Zubair M., Zhang M., Jia D., Zhao X., Liang J., Majid T., Yan J., Farzand A., Wu H., Gu Q., Gao X. Fengycin produced by Bacillus amyloliquefaciens FZB42 inhibits Fusarium graminearum growth and mycotoxins biosynthesis // Toxins (Basel). 2019. V. 11. N5. pp. 295. DOI: 10.3390/toxins11050295Zakharova A.A., Efimova S.S., Malev V.V., Ostroumova O.S. Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes // Sci Rep. 2019. V. 9. N1. P. 16‐34. DOI: 10.1038/s41598‐019‐52551‐5Zakharova A.A., Efimova S.S., Malev V.V., Ostroumova O.S. Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes // Sci Rep. 2019. V. 9. N1. P. 16‐34. DOI: 10.1038/s41598‐019‐52551‐5Sa R.B., An X., Sui J.K., Wang X.H., Ji C., Wang C.Q., Li Q., Hu Y.R., Liu X. Purification and structural characterization of fengycin homologues produced by Bacillus subtilis from poplar wood bark // Australas. Plant Pathol. 2018. V. 47. P. 259‐268. DOI: 10.1007/s13313‐018‐0552‐1Sa R.B., An X., Sui J.K., Wang X.H., Ji C., Wang C.Q., Li Q., Hu Y.R., Liu X. Purification and structural characterization of fengycin homologues produced by Bacillus subtilis from poplar wood bark // Australas. Plant Pathol. 2018. V. 47. P. 259‐268. DOI: 10.1007/s13313‐018‐0552‐1Kaki A.A., Smargiasso N., Ongena M., Ali M.K., Moula N., de Pauw E., Chaouche N.K. Characterization of new fengycin cyclic lipopeptide variants produced by Bacillus amyloliquefaciens (ET) originating from a Salt Lake of Eastern Algeria // Curr Microbiol. 2020. V. 77. P. 443‐451. DOI: 10.1007/s00284‐019‐01855‐wKaki A.A., Smargiasso N., Ongena M., Ali M.K., Moula N., de Pauw E., Chaouche N.K. Characterization of new fengycin cyclic lipopeptide variants produced by Bacillus amyloliquefaciens (ET) originating from a Salt Lake of Eastern Algeria // Curr Microbiol. 2020. V. 77. P. 443‐451. DOI: 10.1007/s00284‐019‐01855‐wYaseen Y., Gancel F., Drider D., Béchet M., Jacques P. Influence of promoters on the production of fengycin in Bacillus spp. // Res. Microbiol. 2016. V. 167. P. 272‐281. DOI: 10.1016/j.resmic.2016.01.008Yaseen Y., Gancel F., Drider D., Béchet M., Jacques P. Influence of promoters on the production of fengycin in Bacillus spp. // Res. Microbiol. 2016. V. 167. P. 272‐281. DOI: 10.1016/j.resmic.2016.01.008Zhou S., Liu G., Zheng R., Sun C., Wu S. Structural and functional insights into iturin W, a novel lipopeptide produced by deep‐sea bacterium Bacillus sp. strain WSM‐1 // Appl. environ. microbiology. 2020. V. 86. N21. DOI: 10.1128/AEM.01597‐20Zhou S., Liu G., Zheng R., Sun C., Wu S. Structural and functional insights into iturin W, a novel lipopeptide produced by deep‐sea bacterium Bacillus sp. strain WSM‐1 // Appl. environ. microbiology. 2020. V. 86. N21. DOI: 10.1128/AEM.01597‐20Dunlap C.A., Bowman M.J., Rooney A.P. Iturinic lipopeptide diversity in the Bacillus subtilis species group important antifungals for plant disease biocontrol applications // Front Microbiol. 2019. V. 10. 1794. DOI: 10.3389/fmicb.2019.01794Dunlap C.A., Bowman M.J., Rooney A.P. Iturinic lipopeptide diversity in the Bacillus subtilis species group important antifungals for plant disease biocontrol applications // Front Microbiol. 2019. V. 10. 1794. DOI: 10.3389/fmicb.2019.01794Lee T., Park D., Kim K., Lim S.M., Yu N.H., Kim S., Kim H.Y., Jung K.S., Jang J.Y., Park J.C., et al. Characterization of Bacillus amyloliquefaciens DA12 showing potent antifungal activity against mycotoxigenic Fusarium species // Plant Pathol. J. 2017. V. 33. P. 499‐507. DOI: 10.5423/PPJ.FT.06.2017.0126Lee T., Park D., Kim K., Lim S.M., Yu N.H., Kim S., Kim H.Y., Jung K.S., Jang J.Y., Park J.C., et al. Characterization of Bacillus amyloliquefaciens DA12 showing potent antifungal activity against mycotoxigenic Fusarium species // Plant Pathol. J. 2017. V. 33. P. 499‐507. DOI: 10.5423/PPJ.FT.06.2017.0126Cao Y., Pi H., Chandrangsu P., Li Y., Wang Y., Zhou H., Xiong H., Helmann J.D., Cai Y. Antagonism of two plant-growth promoting Bacillus velezensis isolates against Ralstonia solanacearum and Fusarium oxysporum // Sci. Rep. 2018. V. 8. DOI: 10.1038/s41598‐018‐22782‐zCao Y., Pi H., Chandrangsu P., Li Y., Wang Y., Zhou H., Xiong H., Helmann J.D., Cai Y. Antagonism of two plant-growth promoting Bacillus velezensis isolates against Ralstonia solanacearum and Fusarium oxysporum // Sci. Rep. 2018. V. 8. DOI: 10.1038/s41598‐018‐22782‐zDe Souza C.G., Martins F.I.C.C., Zocolo G.J., Figueiredo J.E.F., Canuto K.M., de Brito E.S. Simultaneous quantification of lipopeptide isoforms by UPLC‐MS in the fermentation broth from Bacillus subtilis CNPMS22 // Anal. Bioanal.Chem. 2018. V. 41. P. 6827‐6836. DOI: 10.1007/s00216‐018‐1281‐6De Souza C.G., Martins F.I.C.C., Zocolo G.J., Figueiredo J.E.F., Canuto K.M., de Brito E.S. Simultaneous quantification of lipopeptide isoforms by UPLC‐MS in the fermentation broth from Bacillus subtilis CNPMS22 // Anal. Bioanal.Chem. 2018. V. 41. P. 6827‐6836. DOI: 10.1007/s00216‐018‐1281‐6Kumar M., Brar A., Yadav M., Chawade A., Vivekanand V., Pareek N. Chitinases – potential candidates for enhanced plant resistance towards fungal pathogens // Agriculture. 2018. V. 8. P. 88. DOI: 10.3390/agriculture8070088Kumar M., Brar A., Yadav M., Chawade A., Vivekanand V., Pareek N. Chitinases – potential candidates for enhanced plant resistance towards fungal pathogens // Agriculture. 2018. V. 8. P. 88. DOI: 10.3390/agriculture8070088Gamalero E., Glick B.R. Bacterial modulation of plant ethylene levels // Plant Physiol. 2015. V. 169. N1. P. 13‐22. DOI: 10.1104/pp.15.00284Gamalero E., Glick B.R. Bacterial modulation of plant ethylene levels // Plant Physiol. 2015. V. 169. N1. P. 13‐22. DOI: 10.1104/pp.15.00284Olanrewaju O.S., Ayangbenro A.S., Glick B.R., Babalola O.O. Plant health: feedback effect of root exudates-rhizobiome interactions // Appl Microbiol Biotechnol. 2019. V. 103. N3. P. 1155‐1166. DOI: 10.1007/s00253‐018‐9556‐6Olanrewaju O.S., Ayangbenro A.S., Glick B.R., Babalola O.O. Plant health: feedback effect of root exudates-rhizobiome interactions // Appl Microbiol Biotechnol. 2019. V. 103. N3. P. 1155‐1166. DOI: 10.1007/s00253‐018‐9556‐6Schellenberger R., Touchard M., Clément C., Baillieul F., Cordelier S., Crouzet J., Dorey S. Apoplastic invasion patterns triggering plant immunity: plasma membrane sensing at the frontline // Molecular plant pathology. 2019. V. 20. N11. P. 1602‐1616. DOI: 10.1111/mpp.12857Schellenberger R., Touchard M., Clément C., Baillieul F., Cordelier S., Crouzet J., Dorey S. Apoplastic invasion patterns triggering plant immunity: plasma membrane sensing at the frontline // Molecular plant pathology. 2019. V. 20. N11. P. 1602‐1616. DOI: 10.1111/mpp.12857Hashem A., Tabassum B., Fathi Abd Allah E. Bacillus subtilis: A plant‐growth promoting rhizobacterium that also impacts biotic stress // Saudi J Biol Sci. 2019. V. 26. N6. P. 1291‐1297. DOI: 10.1016/j.sjbs.2019.05.004Hashem A., Tabassum B., Fathi Abd Allah E. Bacillus subtilis: A plant‐growth promoting rhizobacterium that also impacts biotic stress // Saudi J Biol Sci. 2019. V. 26. N6. P. 1291‐1297. DOI: 10.1016/j.sjbs.2019.05.004Jinal N.H., Amaresan N. Evaluation of biocontrol Bacillus species on plant growth promotion and systemic-induced resistant potential against bacterial and fungal wilt‐causing pathogens // Archives of microbiology. 2020. V. 202. P. 1785‐1794. DOI: 10.1007/s00203‐020‐01891‐2Jinal N.H., Amaresan N. Evaluation of biocontrol Bacillus species on plant growth promotion and systemic-induced resistant potential against bacterial and fungal wilt‐causing pathogens // Archives of microbiology. 2020. V. 202. P. 1785‐1794. DOI: 10.1007/s00203‐020‐01891‐2Pršić J., Ongena M. Elicitors of plant immunity triggered by beneficial bacteria // Front. Plant Sci. 2020. V. 11. DOI: 10.3389/fpls.2020.594530Pršić J., Ongena M. Elicitors of plant immunity triggered by beneficial bacteria // Front. Plant Sci. 2020. V. 11. DOI: 10.3389/fpls.2020.594530Sajid M., Ahmad Khan M.S., Singh Cameotra S., Safar Al‐Thubiani A. Biosurfactants: Potential applications as immunomodulator drugs // Immunol Lett. 2020. V. 223. P. 71‐77. DOI: 10.1016/j.imlet.2020.04.003Sajid M., Ahmad Khan M.S., Singh Cameotra S., Safar Al‐Thubiani A. Biosurfactants: Potential applications as immunomodulator drugs // Immunol Lett. 2020. V. 223. P. 71‐77. DOI: 10.1016/j.imlet.2020.04.003Chen S.W., Wang H.T., Shih W.Y., Ciou Y.A., Chang Y.Y., Ananda L., Wang S.Y., Hsu J.T. Application of zearalenone (ZEN)‐detoxifying Bacillus in animal feed decontamination through fermentation // Toxins. 2019. V. 11. N6. P. 330. DOI: 10.3390/toxins11060330Chen S.W., Wang H.T., Shih W.Y., Ciou Y.A., Chang Y.Y., Ananda L., Wang S.Y., Hsu J.T. Application of zearalenone (ZEN)‐detoxifying Bacillus in animal feed decontamination through fermentation // Toxins. 2019. V. 11. N6. P. 330. DOI: 10.3390/toxins11060330Tran V.N., Viktorová J., Ruml, T. Mycotoxins: biotransformation and bioavailability assessment using Caco‐2 cell monolayer // Toxins. 2020. V. 12. N10. P. 628. DOI: 10.3390/toxins12100628Tran V.N., Viktorová J., Ruml, T. Mycotoxins: biotransformation and bioavailability assessment using Caco‐2 cell monolayer // Toxins. 2020. V. 12. N10. P. 628. DOI: 10.3390/toxins12100628Dweba C.C., Filan S., Shimelis H.A., Motaung T.E., Sydenham S., Mwadzingeni L., Tsilo T.J. Fusarium head blight of wheat: pathogenesis and control strategies // Crop protection. 2017. V. 91. P. 114‐122. DOI: 10.1016/j.cropro.2016.10.002Dweba C.C., Filan S., Shimelis H.A., Motaung T.E., Sydenham S., Mwadzingeni L., Tsilo T.J. Fusarium head blight of wheat: pathogenesis and control strategies // Crop protection. 2017. V. 91. P. 114‐122. DOI: 10.1016/j.cropro.2016.10.002Chen Y., Kistler H.C., Ma Z. Fusarium graminearum trichothecene mycotoxins: biosynthesis, regulation, and management // Annu Rev Phytopathol. 2019. V. 57. P. 15‐39. DOI: 10.1146/annurev‐phyto‐082718-100318Chen Y., Kistler H.C., Ma Z. Fusarium graminearum trichothecene mycotoxins: biosynthesis, regulation, and management // Annu Rev Phytopathol. 2019. V. 57. P. 15‐39. DOI: 10.1146/annurev‐phyto‐082718-100318Соколова Г.Д., Глинушкин А.П. Механизмы устойчивости к фунгицидам фитопатогенного гриба Fusarium graminearum // Микология и фитопатология. 2020. N6. С. 391‐403. DOI: 10.31857/S0026364820060112Sokolova G.D., Glinushkin A.P. Mechanisms of resistance to fungicides of the phytopathogenic fungus Fusarium graminearum. Mycology and Phytopathology, 2020, vol. 54, no. 6, pp. 391‐403. (In Russian) DOI: 10.31857/S0026364820060112Wu Q., Kuča K., Humpf H.U., Klímová B., Cramer B. Fate of deoxynivalenol and deoxynivalenol‐3‐glucoside during cereal‐based thermal food processing: a review study // Mycotoxin Res. 2017. V. 33. N1. P. 79‐91. DOI: 10.1007/s12550‐016‐0263‐9Wu Q., Kuča K., Humpf H.U., Klímová B., Cramer B. Fate of deoxynivalenol and deoxynivalenol‐3‐glucoside during cereal‐based thermal food processing: a review study // Mycotoxin Res. 2017. V. 33. N1. P. 79‐91. DOI: 10.1007/s12550‐016‐0263‐9Kovač T., Šarkanj B., Borišev I., Djordjevic A., Jović D., Lončarić A., Babić J., Jozinović A., Krska T., Gangl J., Ezekiel C.N., Sulyok M., Krska R. Fullerol C60 (OH) 24 nanoparticles affect secondary metabolite profile of important foodborne mycotoxigenic fungi in vitro // Toxins (Basel). 2020. V. 12. N4. P. 213. DOI: 10.3390/toxins12040213Kovač T., Šarkanj B., Borišev I., Djordjevic A., Jović D., Lončarić A., Babić J., Jozinović A., Krska T., Gangl J., Ezekiel C.N., Sulyok M., Krska R. Fullerol C60 (OH) 24 nanoparticles affect secondary metabolite profile of important foodborne mycotoxigenic fungi in vitro // Toxins (Basel). 2020. V. 12. N4. P. 213. DOI: 10.3390/toxins12040213Ben Taheur F., Kouidhi B., Al Qurashi Y.M.A., Ben Salah‐Abbès J., Chaieb K. Review: biotechnology of mycotoxins detoxification using microorganisms and enzymes // Toxicon. 2019. V. 160. P. 12‐22. DOI: 10.1016/j.toxicon.2019.02.001Ben Taheur F., Kouidhi B., Al Qurashi Y.M.A., Ben Salah‐Abbès J., Chaieb K. Review: biotechnology of mycotoxins detoxification using microorganisms and enzymes // Toxicon. 2019. V. 160. P. 12‐22. DOI: 10.1016/j.toxicon.2019.02.001Luo Y., Liu X., Li J. Updating on controlling mycotoxins a review // Food control. 2018. V. 89. P. 123‐132. DOI: 10.1016/j.foodcont.2018.01/016Luo Y., Liu X., Li J. Updating on controlling mycotoxins a review // Food control. 2018. V. 89. P. 123‐132. DOI: 10.1016/j.foodcont.2018.01/016Iram W., Anjum T., Iqbal M., Ghaffar A., Abbas M. Structural elucidation and toxicity assessment of degraded products of aflatoxin B1 and B2 by aqueous extracts of Trachyspermum ammi // Front. Microbiol. 2016. V. 7. P. 346. DOI: 10.3389/fmicb.2016.00346Iram W., Anjum T., Iqbal M., Ghaffar A., Abbas M. Structural elucidation and toxicity assessment of degraded products of aflatoxin B1 and B2 by aqueous extracts of Trachyspermum ammi // Front. Microbiol. 2016. V. 7. P. 346. DOI: 10.3389/fmicb.2016.00346Adebo O.A., Njobeh P.B., Gbashi S., Nwinyi O.C., Mavumengwana V. Review on microbial degradation of aflatoxins Crit // Rev. Food Sci. Nutr. 2017. vol. 57. N15. P. 3208‐3217. DOI: 10.1080/10408398.2015.1106440Adebo O.A., Njobeh P.B., Gbashi S., Nwinyi O.C., Mavumengwana V. Review on microbial degradation of aflatoxins Crit // Rev. Food Sci. Nutr. 2017. vol. 57. N15. P. 3208‐3217. DOI: 10.1080/10408398.2015.1106440Zhu Y., Hassan Y.I., Lepp D., Shao S., Zhou T. Strategies and methodologies for developing microbial detoxification systems to mitigate mycotoxins // Toxins. 2017. V. 9, no. 4, pp. 130. https://doi.org/10.3390/toxins9040130Zhu Y., Hassan Y.I., Lepp D., Shao S., Zhou T. Strategies and methodologies for developing microbial detoxification systems to mitigate mycotoxins // Toxins. 2017. V. 9, no. 4, pp. 130. https://doi.org/10.3390/toxins9040130Li P., Su R., Yin R., Lai D., Wang M., Liu Y., Zhou L. Detoxication of micotoxication thrugh biotransformation // Toxins. 2020. V. 12. P. 121. DOI: 10.3390/toxins12020121Li P., Su R., Yin R., Lai D., Wang M., Liu Y., Zhou L. Detoxication of micotoxication thrugh biotransformation // Toxins. 2020. V. 12. P. 121. DOI: 10.3390/toxins12020121Vanhoutte J., Audenaert K., Gelder L. Biodegradation of mycotoxins: tales from known and unexplored worlds // Front. Microbiоl. 2016. V. 7. P. 561. DOI: 10.3389/fmicb.2016.00561Vanhoutte J., Audenaert K., Gelder L. Biodegradation of mycotoxins: tales from known and unexplored worlds // Front. Microbiоl. 2016. V. 7. P. 561. DOI: 10.3389/fmicb.2016.00561Wilson N.M., McMaster N., Gantulga D., Soyars C., McCormick S.P., Knoff K., Senger R.S., Schmale D.G. Modification of the mycotoxin deoxynivalenol using microorganisms isolated from environmental samples // Toxins. 2017. V. 9. N4. P. 141. DOI: 10.3390/toxins9040141Wilson N.M., McMaster N., Gantulga D., Soyars C., McCormick S.P., Knoff K., Senger R.S., Schmale D.G. Modification of the mycotoxin deoxynivalenol using microorganisms isolated from environmental samples // Toxins. 2017. V. 9. N4. P. 141. DOI: 10.3390/toxins9040141Wang S., Hou Q., Guo Q., Zhang J., Sun Y., Wei H., Shen L. Isolation and characterization of a deoxynivalenol-degrading bacterium Bacillus licheniformis YB9 with the capability of modulating intestinal microbial flora of mice // Toxins. 2020. V. 12. N3. P. 184. DOI: 10.3390/toxins12030184Wang S., Hou Q., Guo Q., Zhang J., Sun Y., Wei H., Shen L. Isolation and characterization of a deoxynivalenol-degrading bacterium Bacillus licheniformis YB9 with the capability of modulating intestinal microbial flora of mice // Toxins. 2020. V. 12. N3. P. 184. DOI: 10.3390/toxins12030184Jia R., Sadiq F.A., Liu W., Cao L., Shen Z. Protective effects of Bacillus subtilis ASAG 216 on growth performance, antioxidant capacity, gut microbiota and tissues residues of weaned piglets fed deoxynivalenol contaminated diets // Food. Chem. Toxicol. 2021. V. 4. DOI: 10.1016/j.fct.2020.111962Jia R., Sadiq F.A., Liu W., Cao L., Shen Z. Protective effects of Bacillus subtilis ASAG 216 on growth performance, antioxidant capacity, gut microbiota and tissues residues of weaned piglets fed deoxynivalenol contaminated diets // Food. Chem. Toxicol. 2021. V. 4. DOI: 10.1016/j.fct.2020.111962He J.W., Bondy G.S., Zhou T., Caldwell D., Boland G.J., Scott P.M. Toxicology of 3‐epi‐deoxynivalenol, a deoxynivalenol‐transformation product by Devosia mutans 17‐2‐E‐8 // Food Chem. Toxicol. 2015. V. 84. P. 250‐259. DOI: 10.1016/j.fct.2015.09.003He J.W., Bondy G.S., Zhou T., Caldwell D., Boland G.J., Scott P.M. Toxicology of 3‐epi‐deoxynivalenol, a deoxynivalenol‐transformation product by Devosia mutans 17‐2‐E‐8 // Food Chem. Toxicol. 2015. V. 84. P. 250‐259. DOI: 10.1016/j.fct.2015.09.003Snini S.P., Mathieu F. Biocontrol agents and natural compounds against mycotoxinogenic fungi // Toxins. 2020. V. 12. P. 353. DOI: 10.3390/toxins12060353Snini S.P., Mathieu F. Biocontrol agents and natural compounds against mycotoxinogenic fungi // Toxins. 2020. V. 12. P. 353. DOI: 10.3390/toxins12060353He W.J., Yuan Q.S., Zhang Y.B., Guo M.W., Gong A.D., Zhang J.B., Wu A.B., Huang T., Qu B., Li H.P., Liao Y.C. Aerobic de‐epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment // Toxins. 2016. V. 8. Iss. 10. DOI: 10.3390/toxins8100277He W.J., Yuan Q.S., Zhang Y.B., Guo M.W., Gong A.D., Zhang J.B., Wu A.B., Huang T., Qu B., Li H.P., Liao Y.C. Aerobic de‐epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment // Toxins. 2016. V. 8. Iss. 10. DOI: 10.3390/toxins8100277Jimenez‐Sanchez C., Wilson N., McMaster N., Gantulga D., Freedman B.G., Senger R., Schmale D. A mycotoxin transporter (4D) frjm a library of deoxynivalenol‐tolerant microorganisms // ToxiconX. 2020. V. 5. DOI: 10.1016/j.toxcx.2020.100023Jimenez‐Sanchez C., Wilson N., McMaster N., Gantulga D., Freedman B.G., Senger R., Schmale D. A mycotoxin transporter (4D) frjm a library of deoxynivalenol‐tolerant microorganisms // ToxiconX. 2020. V. 5. DOI: 10.1016/j.toxcx.2020.100023Tian Y., Tan Y., Liu N., Liao Y., Sun C., Wang S., Wu A. Functional agents to biologically control deoxynivalenol contamination in cereal grains. Front Microbiol., 2016, vol. 7, pp. 395. DOI: 10.3389/fmicb.2016.00395Tian Y., Tan Y., Liu N., Liao Y., Sun C., Wang S., Wu A. Functional agents to biologically control deoxynivalenol contamination in cereal grains. Front Microbiol., 2016, vol. 7, pp. 395. DOI: 10.3389/fmicb.2016.00395Yao Y., Long M. The biological detoxification of deoxynivalenol: A review // Food chem toxicol. 2020. V. 145. DOI: 10.1016/j.fct.2020.111649Yao Y., Long M. The biological detoxification of deoxynivalenol: A review // Food chem toxicol. 2020. V. 145. DOI: 10.1016/j.fct.2020.111649Bryła M., Waśkiewicz A., Ksieniewicz‐Woźniak E., Szymczyk K., Jędrzejczak R. Modified Fusarium mycotoxins in cereals and their products‐metabolism, occurrence, and toxicity: an updated review // Molecules (Basel, Switzerland). 2018. V. 23. N4. P. 963. DOI: 10.3390/molecules23040963Bryła M., Waśkiewicz A., Ksieniewicz‐Woźniak E., Szymczyk K., Jędrzejczak R. Modified Fusarium mycotoxins in cereals and their products‐metabolism, occurrence, and toxicity: an updated review // Molecules (Basel, Switzerland). 2018. V. 23. N4. P. 963. DOI: 10.3390/molecules23040963Chen S.W., Wang H.T., Shih W.Y., Ciou Y.A., Chang Y.Y., Ananda L., Wang S.Y., Hsu J.T. Application of zearalenone (ZEN)‐detoxifying Bacillus in animal feed decontamination through fermentation // Toxins (Basel). 2019. V. 11. N6. P. 330. DOI: 10.3390/toxins.11060330Chen S.W., Wang H.T., Shih W.Y., Ciou Y.A., Chang Y.Y., Ananda L., Wang S.Y., Hsu J.T. Application of zearalenone (ZEN)‐detoxifying Bacillus in animal feed decontamination through fermentation // Toxins (Basel). 2019. V. 11. N6. P. 330. DOI: 10.3390/toxins.11060330Abdallah M.F., De Boevre M., Landschoot S., De Saeger S., Haesaert G., Audenaert K. Fungal еndophytes сontrolFusarium graminearum and reduce trichothecenes and zearalenone in maize // Toxins. 2018. V. 10. N12. P. 493. DOI: 10.3390/toxins10120493Abdallah M.F., De Boevre M., Landschoot S., De Saeger S., Haesaert G., Audenaert K. Fungal еndophytes сontrolFusarium graminearum and reduce trichothecenes and zearalenone in maize // Toxins. 2018. V. 10. N12. P. 493. DOI: 10.3390/toxins10120493Dunlap C.A., Schisler D.A., Price N.P., Vaughn S.F. Cyclic lipopeptide profile of three Bacillus subtilis strains; antagonists of Fusarium head blight // J Microbiol. 2011. V. 49. N4. P. 603‐609. DOI: 10.1007/s12275‐011‐1044‐yDunlap C.A., Schisler D.A., Price N.P., Vaughn S.F. Cyclic lipopeptide profile of three Bacillus subtilis strains; antagonists of Fusarium head blight // J Microbiol. 2011. V. 49. N4. P. 603‐609. DOI: 10.1007/s12275‐011‐1044‐yCao K., Guan M., Chen K., Lin Y., Luo C. Screening of Fusarium graminearum and degradation of vomitoxin B. amyloliquefaciens and its application in feed storange // Enviromental chemistry. 2019. V. 16. N3. P. 179‐186. DOI: 10.1071/EN18176Cao K., Guan M., Chen K., Lin Y., Luo C. Screening of Fusarium graminearum and degradation of vomitoxin B. amyloliquefaciens and its application in feed storange // Enviromental chemistry. 2019. V. 16. N3. P. 179‐186. DOI: 10.1071/EN18176Chan Y.K., Savard M.E., Reid L.M., Cyr T., McCormick W.A., Seguin C. Identification of lipopeptide antibiotics of a Bacillus subtilis isolate and their control of Fusarium graminearum diseases in maize and wheat // BioControl. 2009. V. 54. P. 567. DOI: 10.1007/s10526‐008‐9201‐xChan Y.K., Savard M.E., Reid L.M., Cyr T., McCormick W.A., Seguin C. Identification of lipopeptide antibiotics of a Bacillus subtilis isolate and their control of Fusarium graminearum diseases in maize and wheat // BioControl. 2009. V. 54. P. 567. DOI: 10.1007/s10526‐008‐9201‐xYu Z., Ding K., Liu S., Li Y., Li W., Li Y., Cao P., Liu Y., Sun E. Screening and identification of a Bacillus cereus degrading vomitotoxin // Food sci. 2016. V. 37. P. 121‐125.Yu Z., Ding K., Liu S., Li Y., Li W., Li Y., Cao P., Liu Y., Sun E. Screening and identification of a Bacillus cereus degrading vomitotoxin // Food sci. 2016. V. 37. P. 121‐125.Jian T., Yang S., Su H., Wu Y., Tong Y. Identification and degradation effect of a Bacillus subtilis degrading vomitotoxin // Contemporary chem. 2018. V. 47. P. 548‐551.Jian T., Yang S., Su H., Wu Y., Tong Y. Identification and degradation effect of a Bacillus subtilis degrading vomitotoxin // Contemporary chem. 2018. V. 47. P. 548‐551.Shi C., Yan P., Li J., Wu H., Li Q., Guan S. Biocontrol of Fusarium graminearum growth and deoxynivalenol production in wheat kernels with bacterial antagonists // Int J Environ Res Public Health. 2014. V. 11. N1. P. 100‐113. DOI: 10.3390/ijerph110101094Shi C., Yan P., Li J., Wu H., Li Q., Guan S. Biocontrol of Fusarium graminearum growth and deoxynivalenol production in wheat kernels with bacterial antagonists // Int J Environ Res Public Health. 2014. V. 11. N1. P. 100‐113. DOI: 10.3390/ijerph110101094Vanhoutte I., De Mets L., De Boevre M., Uka V., Di Mavungu J.D., De Saeger S., De Gelder L., Audenaert K. Microbial detoxification of deoxynivalenol (DON), assessed via a Lemna minor l. bioassay, through biotransformation to 3‐epi‐don and 3‐epi‐dom‐1 // Toxins (Basel). 2017. V. 9. N2. DOI: 10.3390/toxins9020063Vanhoutte I., De Mets L., De Boevre M., Uka V., Di Mavungu J.D., De Saeger S., De Gelder L., Audenaert K. Microbial detoxification of deoxynivalenol (DON), assessed via a Lemna minor l. bioassay, through biotransformation to 3‐epi‐don and 3‐epi‐dom‐1 // Toxins (Basel). 2017. V. 9. N2. DOI: 10.3390/toxins9020063Mingmongkolchai S., Panbangred W. Bacillus probiotics: an alternative to antibiotics for livestock production // J. Аppl. Microbial. 2018. V. 124. P. 1334-1346. DOI: 10.1111/jam.13690Mingmongkolchai S., Panbangred W. Bacillus probiotics: an alternative to antibiotics for livestock production // J. Аppl. Microbial. 2018. V. 124. P. 1334-1346. DOI: 10.1111/jam.13690

The authors declare that there are no conflicts of interest present.